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The Cancer News

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Perspectives

This section features opinion pieces, reflections, and expert commentary on timely or overlooked issues in cancer care, research, and the oncology workforce.

The Silent Ecosystem Within Clinical Trials
Research · Health Equity · Perspectives

The Silent Ecosystem Within Clinical Trials

By Zoë Swainson, MHA

Clinical trial outcomes do not emerge solely by science. They also emerge from an invisible ecosystem of trust, coordination, compassion and operational excellence.

Using MRD Testing to Decide When Multiple Myeloma Maintenance Can Stop
Cancer Education · Perspectives

Using MRD Testing to Decide When Multiple Myeloma Maintenance Can Stop

By Abdullah Mohammad Khan, MBBS

Indefinite lenalidomide maintenance after transplant has been standard practice in multiple myeloma for years, largely on the strength of older trials that never directly tested whether stopping was safe.

Immunotherapy Is Moving Earlier Into Head and Neck Cancer Treatment
Cancer Education · Research · Perspectives

Immunotherapy Is Moving Earlier Into Head and Neck Cancer Treatment

By Hyunseok Kang, MD, MPH

Head and neck cancer treatment has historically advanced roughly once a decade, but two meaningful updates are arriving together this year

MDS, MECOM-Rearranged Leukemia, and BPDCN: New Data Reshaping Treatment Choices
Cancer Education · Perspectives

MDS, MECOM-Rearranged Leukemia, and BPDCN: New Data Reshaping Treatment Choices

By Cecilia Arana Yi, MD

The VERONA trial finds venetoclax adds no survival benefit in higher-risk MDS; new data illuminate outcomes in MECOM-rearranged AML and BPDCN, where transplant remains the strongest predictor of survival.

Overcoming Language Barriers in Cancer Care
Perspectives · Health Equity · Resources for Cancer Patients

Overcoming Language Barriers in Cancer Care

By Kaila Johnson

Language barriers delay cancer diagnoses and lower screening rates for patients with limited English proficiency. Experts weigh in on interpreter access, cultural competence, and why closing these gaps is critical to equitable cancer care.

The First Positive Phase 3 Trial Ever in Dedifferentiated Liposarcoma Changes a Difficult Conversation
Cancer Education · Research · Perspectives

The First Positive Phase 3 Trial Ever in Dedifferentiated Liposarcoma Changes a Difficult Conversation

By David Savage, MD

Dedifferentiated liposarcoma has had no positive phase 3 trial in its history, and existing chemotherapy options rarely delay progression beyond a few months.

Will Multispecific CAR T-Cell Therapy Replace Single-Target CD19 Treatment in Lymphoma?
Cancer Education · Research · Perspectives

Will Multispecific CAR T-Cell Therapy Replace Single-Target CD19 Treatment in Lymphoma?

By Saurabh Dahiya, MD, FACP

CD19-directed CAR T-cell therapy has transformed care for B-cell lymphomas, but most patients still relapse, often due to loss of the CD19 target.

Early-Stage Breast Cancer: Why Fewer Patients Need Chemotherapy, and More Need CDK4/6 Inhibitors
Research · Cancer Education · Perspectives

Early-Stage Breast Cancer: Why Fewer Patients Need Chemotherapy, and More Need CDK4/6 Inhibitors

By Ruta Rao, MD

Genomic testing is increasingly identifying which early-stage, hormone receptor-positive breast cancer patients can safely skip chemotherapy, even among some node-positive premenopausal women.

Beyond G12C: KRAS Lung Cancer Is About to Become a Toolkit, Not a Single Target
Research · Cancer Education · Perspectives

Beyond G12C: KRAS Lung Cancer Is About to Become a Toolkit, Not a Single Target

By Benjamin Herzberg, MD

KRAS G12C is not the only KRAS mutation worth worrying about, and I think that idea is very close to being obsolete.

Head and Neck Cancer: New Antibodies After Checkpoint Failure, and Rethinking Immunotherapy Plus Radiation
Research · Cancer Education · Perspectives

Head and Neck Cancer: New Antibodies After Checkpoint Failure, and Rethinking Immunotherapy Plus Radiation

By Weining Ken Zhen, MD

Developing new strategies for advanced head and neck cancer after checkpoint inhibitor and chemotherapy failures.

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