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Research
The volume and pace of cancer research, from preclinical studies to clinical trials and FDA approvals, can make it challenging to stay informed. This section highlights the latest developments and translates complex scientific concepts into clear, accessible insights for both healthcare professionals and the broader public.
Novel Agents and MRD-Guided Therapy Are Reshaping Frontline Lymphoma Care
By Joe Schroers-Martin, MD
Bruton's tyrosine kinase (BTK) inhibitor combinations now anchor frontline mantle cell lymphoma treatment across age and fitness categories, including chemotherapy-free regimens for older patients and TP53-mutated disease.
Novel Agents and MRD-Guided Therapy Are Reshaping Frontline Lymphoma Care
By Joe Schroers-Martin, MD
Bruton's tyrosine kinase (BTK) inhibitor combinations now anchor frontline mantle cell lymphoma treatment across age and fitness categories, including chemotherapy-free regimens for older patients and TP53-mutated disease.
Novel Agents and MRD-Guided Therapy Are Reshaping Frontline Lymphoma Care
By Joe Schroers-Martin, MD
Bruton's tyrosine kinase (BTK) inhibitor combinations now anchor frontline mantle cell lymphoma treatment across age and fitness categories, including chemotherapy-free regimens for older patients and TP53-mutated disease.
Advanced Chondrosarcoma Finally Has Systemic Treatment Options Under Study
By Varun Monga, MBBS
Conventional chondrosarcoma has historically had no approved systemic therapy given its resistance to chemotherapy and radiation.
Advanced Chondrosarcoma Finally Has Systemic Treatment Options Under Study
By Varun Monga, MBBS
Conventional chondrosarcoma has historically had no approved systemic therapy given its resistance to chemotherapy and radiation.
Advanced Chondrosarcoma Finally Has Systemic Treatment Options Under Study
By Varun Monga, MBBS
Conventional chondrosarcoma has historically had no approved systemic therapy given its resistance to chemotherapy and radiation.
Autologous Transplant in Multiple Myeloma: Still the Standard as Quadruplet Therapy and Cellular Immunotherapy Advance
By Jason Chandler, MD
Autologous stem cell transplant has anchored newly diagnosed multiple myeloma treatment for decades, and every major guideline body still recommends it for eligible patients.
Autologous Transplant in Multiple Myeloma: Still the Standard as Quadruplet Therapy and Cellular Immunotherapy Advance
By Jason Chandler, MD
Autologous stem cell transplant has anchored newly diagnosed multiple myeloma treatment for decades, and every major guideline body still recommends it for eligible patients.
Autologous Transplant in Multiple Myeloma: Still the Standard as Quadruplet Therapy and Cellular Immunotherapy Advance
By Jason Chandler, MD
Autologous stem cell transplant has anchored newly diagnosed multiple myeloma treatment for decades, and every major guideline body still recommends it for eligible patients.
Perioperative Intensification in High-Risk Prostate Cancer: PROTEUS, TALAPRO-3, and Treatment De-Escalation
By Putao Cen, MD
Perioperative intensification is reshaping treatment for high-risk localized and metastatic castration-sensitive prostate cancer.
Perioperative Intensification in High-Risk Prostate Cancer: PROTEUS, TALAPRO-3, and Treatment De-Escalation
By Putao Cen, MD
Perioperative intensification is reshaping treatment for high-risk localized and metastatic castration-sensitive prostate cancer.
Perioperative Intensification in High-Risk Prostate Cancer: PROTEUS, TALAPRO-3, and Treatment De-Escalation
By Putao Cen, MD
Perioperative intensification is reshaping treatment for high-risk localized and metastatic castration-sensitive prostate cancer.
Immunotherapy Is Moving Earlier Into Head and Neck Cancer Treatment
By Hyunseok Kang, MD, MPH
Head and neck cancer treatment has historically advanced roughly once a decade, but two meaningful updates are arriving together this year
Immunotherapy Is Moving Earlier Into Head and Neck Cancer Treatment
By Hyunseok Kang, MD, MPH
Head and neck cancer treatment has historically advanced roughly once a decade, but two meaningful updates are arriving together this year
Immunotherapy Is Moving Earlier Into Head and Neck Cancer Treatment
By Hyunseok Kang, MD, MPH
Head and neck cancer treatment has historically advanced roughly once a decade, but two meaningful updates are arriving together this year
The New Frontier in Lung Cancer Therapy: Targeted Therapy, and Bispecific Antibodies.
By Robert Lin, MD
Adjuvant targeted therapy already has a track record in early-stage non-small cell lung cancer (NSCLC) driven by EGFR or ALK alterations, where it has meaningfully reduced recurrence after surgery.
The New Frontier in Lung Cancer Therapy: Targeted Therapy, and Bispecific Antibodies.
By Robert Lin, MD
Adjuvant targeted therapy already has a track record in early-stage non-small cell lung cancer (NSCLC) driven by EGFR or ALK alterations, where it has meaningfully reduced recurrence after surgery.
The New Frontier in Lung Cancer Therapy: Targeted Therapy, and Bispecific Antibodies.
By Robert Lin, MD
Adjuvant targeted therapy already has a track record in early-stage non-small cell lung cancer (NSCLC) driven by EGFR or ALK alterations, where it has meaningfully reduced recurrence after surgery.
Resistance to KRAS Inhibitors Is Multilayered, and Lineage Plasticity Deserves More Attention
By Konstantin Dragnev, MD
Resistance to KRAS inhibitors should be understood as three distinct categories, primary/intrinsic, adaptive/non-genetic, and acquired/genetic, each with different mechanisms and different implications for how to sequence or combine therapy.
Resistance to KRAS Inhibitors Is Multilayered, and Lineage Plasticity Deserves More Attention
By Konstantin Dragnev, MD
Resistance to KRAS inhibitors should be understood as three distinct categories, primary/intrinsic, adaptive/non-genetic, and acquired/genetic, each with different mechanisms and different implications for how to sequence or combine therapy.
Resistance to KRAS Inhibitors Is Multilayered, and Lineage Plasticity Deserves More Attention
By Konstantin Dragnev, MD
Resistance to KRAS inhibitors should be understood as three distinct categories, primary/intrinsic, adaptive/non-genetic, and acquired/genetic, each with different mechanisms and different implications for how to sequence or combine therapy.
Early Relapse DLBCL: A Case-Based Guide to CAR T-Cell Referral, Product Selection, and Post-CAR-T Sequencing
By Vipal Durkal, MD
Early relapse diffuse large B-cell lymphoma (DLBCL), defined as relapse within 12 months of frontline therapy, should prompt evaluation for second-line CAR T-cell therapy rather than default salvage chemotherapy and transplant.
Early Relapse DLBCL: A Case-Based Guide to CAR T-Cell Referral, Product Selection, and Post-CAR-T Sequencing
By Vipal Durkal, MD
Early relapse diffuse large B-cell lymphoma (DLBCL), defined as relapse within 12 months of frontline therapy, should prompt evaluation for second-line CAR T-cell therapy rather than default salvage chemotherapy and transplant.
Early Relapse DLBCL: A Case-Based Guide to CAR T-Cell Referral, Product Selection, and Post-CAR-T Sequencing
By Vipal Durkal, MD
Early relapse diffuse large B-cell lymphoma (DLBCL), defined as relapse within 12 months of frontline therapy, should prompt evaluation for second-line CAR T-cell therapy rather than default salvage chemotherapy and transplant.
Castleman Disease: Redefining the Spectrum Between "One Lymph Node" and "Many"
By Joshua Brandstadter, MD, PhD, MSc
Castleman disease is not one disease but a polyclonal lymphoproliferative disorder spanning a spectrum from single-lymph-node (unicentric) to widespread (multicentric) involvement, with an emerging "oligocentric" category recognized in between.
Castleman Disease: Redefining the Spectrum Between "One Lymph Node" and "Many"
By Joshua Brandstadter, MD, PhD, MSc
Castleman disease is not one disease but a polyclonal lymphoproliferative disorder spanning a spectrum from single-lymph-node (unicentric) to widespread (multicentric) involvement, with an emerging "oligocentric" category recognized in between.
Castleman Disease: Redefining the Spectrum Between "One Lymph Node" and "Many"
By Joshua Brandstadter, MD, PhD, MSc
Castleman disease is not one disease but a polyclonal lymphoproliferative disorder spanning a spectrum from single-lymph-node (unicentric) to widespread (multicentric) involvement, with an emerging "oligocentric" category recognized in between.
EGFR Resistance Is Genuinely Heterogeneous, and That Should Change How We Study New Drugs
By Joshua Sabari, MD
Resistance to third-generation EGFR inhibitors is far more heterogeneous than the resistance patterns seen after earlier-generation drugs, and in 40-50% of patients, no single resistance mechanism can even be identified.
EGFR Resistance Is Genuinely Heterogeneous, and That Should Change How We Study New Drugs
By Joshua Sabari, MD
Resistance to third-generation EGFR inhibitors is far more heterogeneous than the resistance patterns seen after earlier-generation drugs, and in 40-50% of patients, no single resistance mechanism can even be identified.
EGFR Resistance Is Genuinely Heterogeneous, and That Should Change How We Study New Drugs
By Joshua Sabari, MD
Resistance to third-generation EGFR inhibitors is far more heterogeneous than the resistance patterns seen after earlier-generation drugs, and in 40-50% of patients, no single resistance mechanism can even be identified.