Tuesday, October 6, 2026
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Targeting Endocrine Resistance: New Sequencing Strategies in Metastatic Breast Cancer
Cancer Education · Research

Targeting Endocrine Resistance: New Sequencing Strategies in Metastatic Breast Cancer

By Jaspreet Kaur, MD

Hormone receptor-positive, HER2-negative metastatic breast cancer that has progressed on a CDK4/6 inhibitor now has multiple biomarker-guided options

Leptomeningeal Disease Is Becoming More Common, and Also More Treatable
Cancer Education · Research

Leptomeningeal Disease Is Becoming More Common, and Also More Treatable

By Morana Vojnic, MD, MBA

Leptomeningeal disease (LMD) is becoming more common simply because patients with actionable mutations are living longer

Rethinking Glioblastoma Care: Methylation Status, Tumor Treating Fields, and IDH Inhibitors
Cancer Education · Research

Rethinking Glioblastoma Care: Methylation Status, Tumor Treating Fields, and IDH Inhibitors

By Jerome Graber, MD, MPH

Glioblastoma outcomes with temozolomide depend heavily on MGMT methylation status, a distinction worth revisiting given how often it gets lost in practice.

Sequencing CAR-T and Bispecific Antibodies in Multiple Myeloma: What the Data Show
Cancer Education · Research

Sequencing CAR-T and Bispecific Antibodies in Multiple Myeloma: What the Data Show

By Carolina Schinke, MD

CAR-T cell therapy and bispecific antibodies have transformed relapsed multiple myeloma, but sequencing matters.

The Silent Ecosystem Within Clinical Trials
Research · Health Equity · Perspectives

The Silent Ecosystem Within Clinical Trials

By Zoë Swainson, MHA

Clinical trial outcomes do not emerge solely by science. They also emerge from an invisible ecosystem of trust, coordination, compassion and operational excellence.

HER2-Directed Therapy Is Redefining Frontline Treatment for Gastroesophageal Cancer
Cancer Education · Research

HER2-Directed Therapy Is Redefining Frontline Treatment for Gastroesophageal Cancer

By Manik Amin, MD

Treatment selection for metastatic gastroesophageal adenocarcinoma now proceeds through a structured biomarker sequence.

Using MRD Testing to Decide When Multiple Myeloma Maintenance Can Stop
Cancer Education · Perspectives

Using MRD Testing to Decide When Multiple Myeloma Maintenance Can Stop

By Abdullah Mohammad Khan, MBBS

Indefinite lenalidomide maintenance after transplant has been standard practice in multiple myeloma for years, largely on the strength of older trials that never directly tested whether stopping was safe.

Advanced Chondrosarcoma Finally Has Systemic Treatment Options Under Study
Cancer Education · Research

Advanced Chondrosarcoma Finally Has Systemic Treatment Options Under Study

By Varun Monga, MBBS

Conventional chondrosarcoma has historically had no approved systemic therapy given its resistance to chemotherapy and radiation.

Novel Agents and MRD-Guided Therapy Are Reshaping Frontline Lymphoma Care
Cancer Education · Research

Novel Agents and MRD-Guided Therapy Are Reshaping Frontline Lymphoma Care

By Joe Schroers-Martin, MD

Bruton's tyrosine kinase (BTK) inhibitor combinations now anchor frontline mantle cell lymphoma treatment across age and fitness categories, including chemotherapy-free regimens for older patients and TP53-mutated disease.

Autologous Transplant in Multiple Myeloma: Still the Standard as Quadruplet Therapy and Cellular Immunotherapy Advance
Cancer Education · Research

Autologous Transplant in Multiple Myeloma: Still the Standard as Quadruplet Therapy and Cellular Immunotherapy Advance

By Jason Chandler, MD

Autologous stem cell transplant has anchored newly diagnosed multiple myeloma treatment for decades, and every major guideline body still recommends it for eligible patients.

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