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Perspectives
This section features opinion pieces, reflections, and expert commentary on timely or overlooked issues in cancer care, research, and the oncology workforce.
Multiple Myeloma in 2026: Redefining the Possible — From Three-Year Median Survival to the Threshold of Cure
By Shaji K. Kumar, MD
Median survival in multiple myeloma has grown from three years to potentially fifteen. Dr. Shaji Kumar maps the 2026 treatment landscape — from quadruplet induction to immunotherapy in first relapse and the threshold of cure.
Multiple Myeloma in 2026: Redefining the Possible — From Three-Year Median Survival to the Threshold of Cure
By Shaji K. Kumar, MD
Median survival in multiple myeloma has grown from three years to potentially fifteen. Dr. Shaji Kumar maps the 2026 treatment landscape — from quadruplet induction to immunotherapy in first relapse and the threshold of cure.
Multiple Myeloma in 2026: Redefining the Possible — From Three-Year Median Survival to the Threshold of Cure
By Shaji K. Kumar, MD
Median survival in multiple myeloma has grown from three years to potentially fifteen. Dr. Shaji Kumar maps the 2026 treatment landscape — from quadruplet induction to immunotherapy in first relapse and the threshold of cure.
ASCO 2026: Sima Ehsani Chimeh, MD, on the VIKTORIA-1 Trial in HR+/HER2-Negative Advanced Breast Cancer
By The Cancer News Team
VIKTORIA-1 data show gedatolisib roughly doubled PFS versus alpelisib in PIK3CA-mutant HR+/HER2-negative advanced breast cancer — with a more favorable tolerability profile. An expert breaks down the findings.
ASCO 2026: Sima Ehsani Chimeh, MD, on the VIKTORIA-1 Trial in HR+/HER2-Negative Advanced Breast Cancer
By The Cancer News Team
VIKTORIA-1 data show gedatolisib roughly doubled PFS versus alpelisib in PIK3CA-mutant HR+/HER2-negative advanced breast cancer — with a more favorable tolerability profile. An expert breaks down the findings.
ASCO 2026: Sima Ehsani Chimeh, MD, on the VIKTORIA-1 Trial in HR+/HER2-Negative Advanced Breast Cancer
By The Cancer News Team
VIKTORIA-1 data show gedatolisib roughly doubled PFS versus alpelisib in PIK3CA-mutant HR+/HER2-negative advanced breast cancer — with a more favorable tolerability profile. An expert breaks down the findings.
CAR-T's Real Toxicity Is Delay
By Carolina Escobar, MD
CAR-T physician training centers on managing key toxicities: CRS (fever, hypotension, organ dysfunction) and ICANS (confusion, tremors, seizures).
CAR-T's Real Toxicity Is Delay
By Carolina Escobar, MD
CAR-T physician training centers on managing key toxicities: CRS (fever, hypotension, organ dysfunction) and ICANS (confusion, tremors, seizures).
CAR-T's Real Toxicity Is Delay
By Carolina Escobar, MD
CAR-T physician training centers on managing key toxicities: CRS (fever, hypotension, organ dysfunction) and ICANS (confusion, tremors, seizures).
ASCO 2026: Expert Commentary on the SUCCESSOR-2 Trial in Relapsed/Refractory Multiple Myeloma
By The Cancer News Team
SUCCESSOR-2 extended median PFS to 18 months with mezigdomide plus carfilzomib and dexamethasone in relapsed/refractory myeloma. An expert weighs in on what the phase 3 results mean for community practice.
ASCO 2026: Expert Commentary on the SUCCESSOR-2 Trial in Relapsed/Refractory Multiple Myeloma
By The Cancer News Team
SUCCESSOR-2 extended median PFS to 18 months with mezigdomide plus carfilzomib and dexamethasone in relapsed/refractory myeloma. An expert weighs in on what the phase 3 results mean for community practice.
ASCO 2026: Expert Commentary on the SUCCESSOR-2 Trial in Relapsed/Refractory Multiple Myeloma
By The Cancer News Team
SUCCESSOR-2 extended median PFS to 18 months with mezigdomide plus carfilzomib and dexamethasone in relapsed/refractory myeloma. An expert weighs in on what the phase 3 results mean for community practice.
ASCO 2026: Sunvozertinib & Selpercatinib in Lung Cancer
By The Cancer News Team
WU-KONG28 and LIBRETTO-432 delivered practice-changing data at ASCO 2026 for molecularly defined NSCLC. A thoracic oncologist breaks down what sunvozertinib and selpercatinib mean for frontline and adjuvant care.
ASCO 2026: Sunvozertinib & Selpercatinib in Lung Cancer
By The Cancer News Team
WU-KONG28 and LIBRETTO-432 delivered practice-changing data at ASCO 2026 for molecularly defined NSCLC. A thoracic oncologist breaks down what sunvozertinib and selpercatinib mean for frontline and adjuvant care.
ASCO 2026: Sunvozertinib & Selpercatinib in Lung Cancer
By The Cancer News Team
WU-KONG28 and LIBRETTO-432 delivered practice-changing data at ASCO 2026 for molecularly defined NSCLC. A thoracic oncologist breaks down what sunvozertinib and selpercatinib mean for frontline and adjuvant care.
What Every Oncologist Needs to Know About CAR-T Toxicity
By John Mathews, MD
CAR-T toxicity doesn't end at the cancer center — it follows patients home. A community oncologist's guide to recognizing and managing CRS, IEC-HS, ICANS, late infections, and delayed neurotoxicity.
What Every Oncologist Needs to Know About CAR-T Toxicity
By John Mathews, MD
CAR-T toxicity doesn't end at the cancer center — it follows patients home. A community oncologist's guide to recognizing and managing CRS, IEC-HS, ICANS, late infections, and delayed neurotoxicity.
What Every Oncologist Needs to Know About CAR-T Toxicity
By John Mathews, MD
CAR-T toxicity doesn't end at the cancer center — it follows patients home. A community oncologist's guide to recognizing and managing CRS, IEC-HS, ICANS, late infections, and delayed neurotoxicity.
Sarcoma Treatment in 2026: From Gerald Ford’s Drugs to Trabectedin and Pembrolizumab
By Lee Cranmer, MD/PhD/FACP
The pace of drug approvals has accelerated, and the field is moving, cautiously, away from one-size-fits-all cytotoxic therapy toward biologically informed treatment.
Sarcoma Treatment in 2026: From Gerald Ford’s Drugs to Trabectedin and Pembrolizumab
By Lee Cranmer, MD/PhD/FACP
The pace of drug approvals has accelerated, and the field is moving, cautiously, away from one-size-fits-all cytotoxic therapy toward biologically informed treatment.
Sarcoma Treatment in 2026: From Gerald Ford’s Drugs to Trabectedin and Pembrolizumab
By Lee Cranmer, MD/PhD/FACP
The pace of drug approvals has accelerated, and the field is moving, cautiously, away from one-size-fits-all cytotoxic therapy toward biologically informed treatment.
ASCENT-03, ASCENT-04, and Dato-DXd: How ADCs Are Replacing Chemotherapy in Metastatic TNBC
By Vijayakrishna Gadi, PhD, MD
ADCs are now first-line options in metastatic TNBC regardless of PD-L1 status. Dr. VK Gadi breaks down ASCENT-03, ASCENT-04, and Dato-DXd—and what's coming next in a rapidly shifting treatment landscape.
ASCENT-03, ASCENT-04, and Dato-DXd: How ADCs Are Replacing Chemotherapy in Metastatic TNBC
By Vijayakrishna Gadi, PhD, MD
ADCs are now first-line options in metastatic TNBC regardless of PD-L1 status. Dr. VK Gadi breaks down ASCENT-03, ASCENT-04, and Dato-DXd—and what's coming next in a rapidly shifting treatment landscape.
ASCENT-03, ASCENT-04, and Dato-DXd: How ADCs Are Replacing Chemotherapy in Metastatic TNBC
By Vijayakrishna Gadi, PhD, MD
ADCs are now first-line options in metastatic TNBC regardless of PD-L1 status. Dr. VK Gadi breaks down ASCENT-03, ASCENT-04, and Dato-DXd—and what's coming next in a rapidly shifting treatment landscape.
"I Think of Myself as a Plumber": The Engineer Trying to Fix Global Diagnostic Inequity
By Ariana Sutherland, MSc
"I think of myself as a plumber by training," Ayokunle Olanrewaju, PhD, says to a room of oncology healthcare providers.
"I Think of Myself as a Plumber": The Engineer Trying to Fix Global Diagnostic Inequity
By Ariana Sutherland, MSc
"I think of myself as a plumber by training," Ayokunle Olanrewaju, PhD, says to a room of oncology healthcare providers.
"I Think of Myself as a Plumber": The Engineer Trying to Fix Global Diagnostic Inequity
By Ariana Sutherland, MSc
"I think of myself as a plumber by training," Ayokunle Olanrewaju, PhD, says to a room of oncology healthcare providers.
Mantle Cell Lymphoma in 2026: Auto-Transplant's Role Is fading, BTKi Combinations Are Frontline, and Brexu-cel Has Five-Year Data in RR-MCL
By Preetesh Jain, MD, DM, PhD
Mantle cell lymphoma is biologically diverse, clinically unpredictable, and historically difficult to treat with sustained efficacy.
Mantle Cell Lymphoma in 2026: Auto-Transplant's Role Is fading, BTKi Combinations Are Frontline, and Brexu-cel Has Five-Year Data in RR-MCL
By Preetesh Jain, MD, DM, PhD
Mantle cell lymphoma is biologically diverse, clinically unpredictable, and historically difficult to treat with sustained efficacy.
Mantle Cell Lymphoma in 2026: Auto-Transplant's Role Is fading, BTKi Combinations Are Frontline, and Brexu-cel Has Five-Year Data in RR-MCL
By Preetesh Jain, MD, DM, PhD
Mantle cell lymphoma is biologically diverse, clinically unpredictable, and historically difficult to treat with sustained efficacy.