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Research
The volume and pace of cancer research, from preclinical studies to clinical trials and FDA approvals, can make it challenging to stay informed. This section highlights the latest developments and translates complex scientific concepts into clear, accessible insights for both healthcare professionals and the broader public.
How to Treat Mantle Cell Lymphoma in 2026
By Yucai Wang, MD, PhD
Frontline treatment for mantle cell lymphoma (MCL) is no longer a simple, one-size-fits-all algorithm split by transplant eligibility
How to Treat Mantle Cell Lymphoma in 2026
By Yucai Wang, MD, PhD
Frontline treatment for mantle cell lymphoma (MCL) is no longer a simple, one-size-fits-all algorithm split by transplant eligibility
How to Treat Mantle Cell Lymphoma in 2026
By Yucai Wang, MD, PhD
Frontline treatment for mantle cell lymphoma (MCL) is no longer a simple, one-size-fits-all algorithm split by transplant eligibility
The First Positive Phase 3 Trial Ever in Dedifferentiated Liposarcoma Changes a Difficult Conversation
By David Savage, MD
Dedifferentiated liposarcoma has had no positive phase 3 trial in its history, and existing chemotherapy options rarely delay progression beyond a few months.
The First Positive Phase 3 Trial Ever in Dedifferentiated Liposarcoma Changes a Difficult Conversation
By David Savage, MD
Dedifferentiated liposarcoma has had no positive phase 3 trial in its history, and existing chemotherapy options rarely delay progression beyond a few months.
The First Positive Phase 3 Trial Ever in Dedifferentiated Liposarcoma Changes a Difficult Conversation
By David Savage, MD
Dedifferentiated liposarcoma has had no positive phase 3 trial in its history, and existing chemotherapy options rarely delay progression beyond a few months.
Will Multispecific CAR T-Cell Therapy Replace Single-Target CD19 Treatment in Lymphoma?
By Saurabh Dahiya, MD, FACP
CD19-directed CAR T-cell therapy has transformed care for B-cell lymphomas, but most patients still relapse, often due to loss of the CD19 target.
Will Multispecific CAR T-Cell Therapy Replace Single-Target CD19 Treatment in Lymphoma?
By Saurabh Dahiya, MD, FACP
CD19-directed CAR T-cell therapy has transformed care for B-cell lymphomas, but most patients still relapse, often due to loss of the CD19 target.
Will Multispecific CAR T-Cell Therapy Replace Single-Target CD19 Treatment in Lymphoma?
By Saurabh Dahiya, MD, FACP
CD19-directed CAR T-cell therapy has transformed care for B-cell lymphomas, but most patients still relapse, often due to loss of the CD19 target.
KSHV-Associated Multicentric Castleman Disease: A Distinct Diagnosis With Distinct Treatment Considerations
By Kathryn Lurain, MD, MPH
KSHV/HHV8-associated multicentric Castleman disease (MCD) shares clinical features with idiopathic multicentric Castleman disease but has a distinct viral cause
KSHV-Associated Multicentric Castleman Disease: A Distinct Diagnosis With Distinct Treatment Considerations
By Kathryn Lurain, MD, MPH
KSHV/HHV8-associated multicentric Castleman disease (MCD) shares clinical features with idiopathic multicentric Castleman disease but has a distinct viral cause
KSHV-Associated Multicentric Castleman Disease: A Distinct Diagnosis With Distinct Treatment Considerations
By Kathryn Lurain, MD, MPH
KSHV/HHV8-associated multicentric Castleman disease (MCD) shares clinical features with idiopathic multicentric Castleman disease but has a distinct viral cause
Kidney Cancer Treatment Diversifies: Dual Immunotherapy, HIF-2α Inhibition, and TKI-Free Intervals
By Randy F. Sweis, MD
Frontline treatment of advanced renal cell carcinoma (RCC) now centers on a choice between dual immunotherapy and immunotherapy-TKI combinations, each with different tradeoffs in response rate versus durable remission.
Kidney Cancer Treatment Diversifies: Dual Immunotherapy, HIF-2α Inhibition, and TKI-Free Intervals
By Randy F. Sweis, MD
Frontline treatment of advanced renal cell carcinoma (RCC) now centers on a choice between dual immunotherapy and immunotherapy-TKI combinations, each with different tradeoffs in response rate versus durable remission.
Kidney Cancer Treatment Diversifies: Dual Immunotherapy, HIF-2α Inhibition, and TKI-Free Intervals
By Randy F. Sweis, MD
Frontline treatment of advanced renal cell carcinoma (RCC) now centers on a choice between dual immunotherapy and immunotherapy-TKI combinations, each with different tradeoffs in response rate versus durable remission.
Early-Stage Breast Cancer: Why Fewer Patients Need Chemotherapy, and More Need CDK4/6 Inhibitors
By Ruta Rao, MD
Genomic testing is increasingly identifying which early-stage, hormone receptor-positive breast cancer patients can safely skip chemotherapy, even among some node-positive premenopausal women.
Early-Stage Breast Cancer: Why Fewer Patients Need Chemotherapy, and More Need CDK4/6 Inhibitors
By Ruta Rao, MD
Genomic testing is increasingly identifying which early-stage, hormone receptor-positive breast cancer patients can safely skip chemotherapy, even among some node-positive premenopausal women.
Early-Stage Breast Cancer: Why Fewer Patients Need Chemotherapy, and More Need CDK4/6 Inhibitors
By Ruta Rao, MD
Genomic testing is increasingly identifying which early-stage, hormone receptor-positive breast cancer patients can safely skip chemotherapy, even among some node-positive premenopausal women.
Beyond G12C: KRAS Lung Cancer Is About to Become a Toolkit, Not a Single Target
By Benjamin Herzberg, MD
KRAS G12C is not the only KRAS mutation worth worrying about, and I think that idea is very close to being obsolete.
Beyond G12C: KRAS Lung Cancer Is About to Become a Toolkit, Not a Single Target
By Benjamin Herzberg, MD
KRAS G12C is not the only KRAS mutation worth worrying about, and I think that idea is very close to being obsolete.
Beyond G12C: KRAS Lung Cancer Is About to Become a Toolkit, Not a Single Target
By Benjamin Herzberg, MD
KRAS G12C is not the only KRAS mutation worth worrying about, and I think that idea is very close to being obsolete.
AL Amyloidosis, POEMS Syndrome, and Extramedullary Myeloma: Diagnosis Lags, Treatment Options Grow
By Jack Khouri, MD
AL amyloidosis remains a frequently missed, "sneaky" diagnosis, but the treatment landscape is genuinely transforming
AL Amyloidosis, POEMS Syndrome, and Extramedullary Myeloma: Diagnosis Lags, Treatment Options Grow
By Jack Khouri, MD
AL amyloidosis remains a frequently missed, "sneaky" diagnosis, but the treatment landscape is genuinely transforming
AL Amyloidosis, POEMS Syndrome, and Extramedullary Myeloma: Diagnosis Lags, Treatment Options Grow
By Jack Khouri, MD
AL amyloidosis remains a frequently missed, "sneaky" diagnosis, but the treatment landscape is genuinely transforming
Enfortumab Vedotin Plus Pembrolizumab Reshapes Bladder Cancer, From Metastatic Disease to Surgery
By David VanderWeele, MD, PhD
For decades, platinum-based chemotherapy (cisplatin- or carboplatin-based regimens combined with gemcitabine) was the mainstay of treatment for metastatic urothelial cancer, with little improvement from added agents.
Enfortumab Vedotin Plus Pembrolizumab Reshapes Bladder Cancer, From Metastatic Disease to Surgery
By David VanderWeele, MD, PhD
For decades, platinum-based chemotherapy (cisplatin- or carboplatin-based regimens combined with gemcitabine) was the mainstay of treatment for metastatic urothelial cancer, with little improvement from added agents.
Enfortumab Vedotin Plus Pembrolizumab Reshapes Bladder Cancer, From Metastatic Disease to Surgery
By David VanderWeele, MD, PhD
For decades, platinum-based chemotherapy (cisplatin- or carboplatin-based regimens combined with gemcitabine) was the mainstay of treatment for metastatic urothelial cancer, with little improvement from added agents.
Head and Neck Cancer: New Antibodies After Checkpoint Failure, and Rethinking Immunotherapy Plus Radiation
By Weining Ken Zhen, MD
Developing new strategies for advanced head and neck cancer after checkpoint inhibitor and chemotherapy failures.
Head and Neck Cancer: New Antibodies After Checkpoint Failure, and Rethinking Immunotherapy Plus Radiation
By Weining Ken Zhen, MD
Developing new strategies for advanced head and neck cancer after checkpoint inhibitor and chemotherapy failures.
Head and Neck Cancer: New Antibodies After Checkpoint Failure, and Rethinking Immunotherapy Plus Radiation
By Weining Ken Zhen, MD
Developing new strategies for advanced head and neck cancer after checkpoint inhibitor and chemotherapy failures.